Princess Margaret Cancer Centre · University Health Network

Computational Cancer Genomics

Unraveling the genetic code of cancer

Research

Welcome to the Computational Cancer Genomics Lab at the Princess Margaret Cancer Centre at the University Health Network. We study the role of genomic variations in driving tumor progression.

Our lab studies cancer biology by building computational tools with state-of-the-art genomics, biophysics, and machine learning techniques. We are looking for enthusiastic researchers and students interested in computational biology to JOIN US!

Rapid declines in sequencing costs have enabled large-scale genome and exome sequencing for various cancer cohorts. A critical shared objective among such studies has been to understand how genomic variants affect tumor etiology. How may we develop robust quantitative models to predict the impact of somatic mutations on gene expression and protein function? Furthermore, how may we leverage these quantitative models to prioritize genomic variants and utilize this knowledge to develop new cancer therapeutics? Our lab is interested in developing integrative methods that use multiple data resources and cross-disciplinary approaches to address questions of this nature.

01 Protein structure research illustration

Protein structure and function

Previously, we have developed methods that integrate protein structure and protein motion information to evaluate the molecular impact of cancer mutations and identify putative cancer driver genes. Currently, we are building machine learning methods integrating protein structure, cancer genomics, and clinical data to identify novel drug targets and predict drugs' efficacy & side effects among cancer patients.

02 Cancer progression schematic

Cooperative cancer drivers

The canonical model of cancer progression dichotomizes cancer mutations as drivers and passengers. However, our recent analysis of thousands of cancer genomes indicates the presence of a continuum where strong and weak drivers can contribute to cancer progression via epistatic interactions or their aggregated/additive effects. As a follow-up to this work, we are currently developing novel methods to investigate the role of cooperative genetic and cellular level interactions in driving tumor growth and metastases.

03 Structural variation schematic

Non-coding and structural variation

The overwhelming majority of cancer mutations fall within non-coding regions of the genome. Clear insights into how non-coding mutations play causal roles in various cancer types remain limited. Similar to non-coding mutations, we have little understanding of how SVs influence cancer progression. My group is interested in building methodologies for understanding the role of non-coding mutations and SVs in different cancer cohorts.

Recent Publications

Explore our full publication list on Google Scholar

Our team

Meet the people behind our research.

View alumni
Nirvana Nursimulu

Nirvana Nursimulu

Postdoctoral Fellow

Nirvana Nursimulu is a postdoctoral researcher in the lab. She completed her undergraduate degree in Bioinformatics and Computational Biology at the University of Toronto, after which she embarked on a journey through graduate school at the University of Toronto studying Computer Science under the supervision of Dr Parkinson and Dr Moses. From her previous work, she remains fascinated by how mathematics can be used to capture biological phenomena and model the growth of parasites. In her free time, she enjoys reading and writing fiction, running, and has occasionally engaged in improvisational theatre.

Nadejda Boev

Nadejda Boev

PhD Student

Nadejda Boev is a PhD student in the Department of Medical Biophysics at the University of Toronto. She completed her undergraduate degree in Biology & Mathematics at Queen's University. In her free time, she enjoys going on walks and listening to podcasts.

Nour Hanafi

Nour Hanafi

PhD Student

Nour Hanafi is a PhD student in the Department of Medical Biophysics at the University of Toronto (U of T). She completed her undergraduate degree in Molecular Biology with a Chemistry minor at U of T Mississauga, an MHSc in Medical Genomics at U of T, and worked as an analyst at the SickKids’ Centre for Computational Medicine. In her free time, she enjoys long walks, trying out new iced drinks, and watching her favorite sports teams, Atletico Madrid and the Toronto Raptors.

Alexander Turco

Alexander Turco

PhD Student

Alexander Turco is a MSc student in the Department of Medical Biophysics at the University of Toronto (U of T). He completed his undergraduate degree in Bioinformatics with a research specialization at McMaster University. In his free time, he enjoys Rubik’s cubes, snowboarding, building computers, and playing his favorite video game, Stardew Valley.

Linghao Song

Linghao Song

PhD Researcher (Co-supervised)

Linghao received his B.S. in Microbiology from Michigan State University (2018) and his M.Sc. in Biomedical Informatics from the University of Chicago (2020). He then worked with the Genomic Data Commons (GDC) group in the Center for Translational Data Science (CTDS) at the University of Chicago (2020-2025). His Ph.D. work, co-supervised by Dr. Rama Khokha, focuses on identifying plasma proteomic and metabolomics signatures in high-breast-cancer-risk germline mutations carriers and exploring potential prevention strategies. Outside of the lab, he likes to play boardgames and ski with friends.

Mingjie Zhao

Mingjie Zhao

MScAC Student

Mingjie Zhao is a MSc student in Applied Computing at the University of Toronto. He completed his undergraduate degree in Statistics and Data Science at the University of Waterloo. Outside of his studies, he enjoys long walks, cooking, and exploring his creativity through drawing and painting.

Sean D’Mello

Sean D’Mello

MSc Student

Sean D’Mello is an MSc student in Medical Biophysics at the University of Toronto and earned his undergraduate degree in Biomedical Engineering from the University of Waterloo. He completed several co-op placements applying machine learning to medicine, including at the ORTHOTron Lab at the University of Waterloo and the Tearney Lab at Massachusetts General Hospital. Outside of academics, Sean enjoys reading, swimming, and camping.

Omar Alawamry

Omar Alawamry

MSc Student

Omar Alawamry is an MSc student in Medical Biophysics at the University of Toronto, co-supervised by Dr. Mélanie Courtot, and earned his undergraduate degree in Biochemistry at McMaster University. He has conducted translational clinical research at Sunnybrook Research Institute, focusing on the development of liquid biopsies using emerging technologies such as imaging flow cytometry. His current interests lie in cancer genomics and the development of bioinformatic tools. In his free time, he enjoys preparing café-style drinks at home and playing tennis.

Lucy Fuccilo

Lucy Fuccilo

Administrative Assistant

Lucy Fuccilo is the administrative assistant for the CCGLab. She has extensive experience working at Princess Margaret Cancer Centre. Outside of the lab Lucy loves to walk her dog Watson, who is extremely cute.

CCG Lab logo

We are looking for enthusiastic researchers and students interested in computational biology and cancer research to JOIN US!

Alumni

  • Saman BazmiML Engineer @ RBC
  • Hayden Yu
  • Wendy WanMSc Student @ University of Toronto
  • Sophia LiMScAC Student @ University of Toronto
  • Yosef Masoudi-SobhanzadehProfessor @ Istanbul Rumeli University
  • Shaoshi ZhangGraduate Student at the University of Western Ontario
  • Grace HuMD Student at the University of Toronto
  • Luke ZhangPhD Student at the University of Toronto
  • Jean YaacoubSoftware Engineer @ Google
  • Yumika ShibaPhD Student at the University of Toronto
  • Victoria ValeevaPhD Student at the University of British Columbia
  • Jackson HoweGraduate Management Rotation @ Labatt

Join our lab

Toronto skyline

Postdoctoral Associate

Job description: Applications are invited for postdoctoral positions in the computational cancer genomics laboratory at the Princess Margaret Cancer Centre. We are interested in working with highly motivated people interested in building tools and analyzing large-scale cancer multi-omics data. They will have opportunities to collaborate with a diverse group of experimental and computational biologists at the Princess Margaret Cancer Centre and the University of Toronto. We are looking for candidates with prior experience in computational biology.

Eligibility requirement: A Ph.D. in computational biology, bioinformatics, genomics, computer science, or a related field is required. A strong computational background, proficiency in at least one programming language, knowledge of machine learning and statistics are also needed.

How to Apply: Interested candidates should send a cover letter, CV, link to their GitHub/another codebase, and names of three references to Dr. Kumar (sushant.kumar@uhnresearch.ca).

Graduate and Undergraduate Students

Interested students should send an email to Dr. Kumar (sushant.kumar@uhnresearch.ca) to discuss potential projects in the lab.

News

Nour Hanafi received a CGS-D award, and Sean D’Mello received a CGS-M award. Many congratulations, Nour and Sean!

Nad received a Canada Graduate Scholarship award from CIHR to pursue her PhD thesis. Many congratulations, Nad!

Alex received a Canada Graduate Scholarship award from CIHR to pursue his MSc thesis. Many congratulations, Alex!

Nour Hanafi received a Marathon of Hope Cancer Centres Network Scholarship award. Many congratulations, Nour!

Earlier news 2022–2023

Nour Hanafi joins the lab to pursue her PhD at MBP. Welcome, Nour!

Nirvana Nursimulu joins the lab as the inaugural CBMP Postdoctoral Fellow. Welcome Nirvana!

Saman Bazmi joins our group as postdoctoral associate. Welcome Saman!

Alexander Turco joined our group for the summer as an undergraduate student researcher. Welcome Alex!

Jackson Howe joined our group for the summer as a UofT Data Science Institute SUDS scholar. Welcome Jackson!

Jean Yaacoub joined the lab for his coop internship as part of his graduate study in the MScAC program at UofT. Welcome Jean!

Sushant attended the annual V summit in Virginia and presented our efforts toward cancer prevention and early detection.

Nad received a Canada Graduate Scholarship award from CIHR to pursue her MSc thesis. Many congratulations, Nad!

Our lab received funding from NSERC to study the evolution of the gene regulation process. We are very grateful for the support.

Nadejda Boev joined the lab for her graduate studies. Welcome, Nad!

Our lab received funding support from the Canada Research Chair Program. We are immensely thankful to CIHR.

Our lab received funding from the V Foundation for Cancer Research as part of the V scholar program. We are very grateful.

Contact

Computational Cancer Genomics Lab

Princess Margaret Cancer Research Tower
University Health Network, University of Toronto
101 College Street
Toronto, ON M5G 0A3